{"id":320,"date":"2007-05-23T19:26:31","date_gmt":"2007-05-23T18:26:31","guid":{"rendered":"https:\/\/www.biestmilch.com\/wordpress\/?p=320"},"modified":"2016-04-30T10:28:27","modified_gmt":"2016-04-30T09:28:27","slug":"genetics-is-a-paradigm-about-to-change","status":"publish","type":"post","link":"https:\/\/www.biestmilch.com\/blog\/2007\/05\/23\/genetics-is-a-paradigm-about-to-change\/","title":{"rendered":"Genetics: Is a paradigm about to change?"},"content":{"rendered":"<p>Today, back to our workshop in Eckernfoerde, Northern Germany. Countess Wolffskeel presented her amazing therapeutic success with biestmilch in genetic diseases like Coffin Lawry syndrome. Her therapeutic rationale is based on the concept of cell milieu modulation and downregulation of the inflammatory pressure the body is embedded in. By cell milieu modulation it is thus possible to alter the patterns of gene expression, and thus compensate for gene defects by a stimulating or depressing milieu respectively. <br \/>Genetic defects are then no inescapable destiny and the DNA is no holy grail anymore. It is \u00bbonly\u00ab an essential component of the loop: RNA, nucleus, cytoplasma and protein synthesis, intracellular signal transduction, cell membrane, cell membrane receptors and extracellular matrix &#8211; a tightly cross-linked system of interdependent elements.<\/p>\n<p><!--more--><\/p>\n<p>And what makes me extraordinarily happy is that biestmilch&#8217;s thought<br \/> concept of mode of action is perfectly fitting the recently pulished<br \/> views on the new gene in one of the world&#8217;s most reputed science<br \/> journals NATURE. And if once an idea made its way into Nature, one<br \/> could assume that a paradigm change is imminent, at least one needs not to feel like an insulated heretic anymore, hopefully&#8230;!<\/p>\n<p><strong>Quotes from NATURE|Vol 441|25 May 2006<\/strong>\u00a0<\/p>\n<p>The idea of genes as beads on a DNA string is fast fading. Protein-coding sequences have no <br \/>clear<br \/> beginning or end and RNA is a key part of the information package.<br \/> Identical twins are not necessarily identical anymore. A longlasting<br \/> secret contradicting the established view on the genetic code is<br \/> finally soundly disclosed.<\/p>\n<ul>\n<li><em>The degree of compelxity we&#8217;ve seen was not anticipated. <\/em><\/li>\n<\/ul>\n<ul>\n<li><em>When we started the ENCODE project I had a different view of what a gene was.<\/em><\/li>\n<\/ul>\n<ul>\n<li><em>The picture the studies paint is one of mind-boggling complexity.<\/em><\/li>\n<\/ul>\n<ul>\n<li><em>We\u2019ve come to the realization that the genome is full of overlapping transcripts.\u00ab<\/em><\/li>\n<\/ul>\n<p>Does this sound like the old dogma of the genetic code conveying<br \/> information only in one direction, from the DNA to protein synthesis<br \/> machinery? No!<br \/>DNA develops into an integral part of the cell and<br \/> its milieu, intertwined into the circular world of feedback loops<br \/> structuring and organizing our body and regulating its dynamic<br \/> equilibrium.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The idea of genes as beads on a DNA string is fast fading. Protein-coding sequences have no<br \/>\nclear beginning or end and RNA is a key part of the information package. Therefore cell milieu modulation may change the course of genetic diseases. Biestmilch is such cell milieu modulator.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[2294],"tags":[],"_links":{"self":[{"href":"https:\/\/www.biestmilch.com\/blog\/wp-json\/wp\/v2\/posts\/320"}],"collection":[{"href":"https:\/\/www.biestmilch.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.biestmilch.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.biestmilch.com\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.biestmilch.com\/blog\/wp-json\/wp\/v2\/comments?post=320"}],"version-history":[{"count":2,"href":"https:\/\/www.biestmilch.com\/blog\/wp-json\/wp\/v2\/posts\/320\/revisions"}],"predecessor-version":[{"id":5124,"href":"https:\/\/www.biestmilch.com\/blog\/wp-json\/wp\/v2\/posts\/320\/revisions\/5124"}],"wp:attachment":[{"href":"https:\/\/www.biestmilch.com\/blog\/wp-json\/wp\/v2\/media?parent=320"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.biestmilch.com\/blog\/wp-json\/wp\/v2\/categories?post=320"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.biestmilch.com\/blog\/wp-json\/wp\/v2\/tags?post=320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}